Neuropharm 2/7/2017 Part I

(Brian Koehler)

Txtbook: Fundamentals of Clinical Psychopharmacology, edited by Anderson and McAllister-Williams/ Neuropsychopharmacology and drug action by Gartside and Marsden.


most drugs-> alter neurotransmission. (either presynaptically in synaptic cleft, or postsynaptically by agonist, antagonist, or modulatory actions at postsynaptic receptors.)

Postsynaptic receptor- 1) excitation (membrane depolarization) 2) inhibition (membrane hyperpolarization)

Fast neurotransmission: through ion channel
Slow neurotransmission: increase or decrease in a second messenger. (indirect effects via a guanine nucleotide-binding G protein to cause the opening of ion channels or the stimulation or inhibition of an enzyme…

Mechanisms other than synaptic:
-extrasynaptic volume transmission
-retrograde signaling
-initial receptor response

Co-existence of neurotransmitters (NTs):
1. norepinephrine (NE)
2. dopamine (DA)
3. 5-hydroxytryptamine (5-HT, serotonin)
4. acetylcholine (Ach)
5. glutamine
6. gama-aminobutyric acid (GABA)

Full NTs v neuromodulators

Co-existence is poorly understood :/




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